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Sensory and Metabolic Control of Energy Balance-[1]-[pdf]-[Hans-Georg Joost (auth.), Wolfgang Meyerhof, Ulrike Beisiegel, Hans-Georg Joost (eds.)]

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    书籍信息:
    标题: Sensory and Metabolic Control of Energy Balance
    语言: English
    格式: pdf
    大小: 3.8M
    页数: 215
    年份: 2010
    作者: Hans-Georg Joost (auth.), Wolfgang Meyerhof, Ulrike Beisiegel, Hans-Georg Joost (eds.)
    版次: 1
    系列: Results and Problems in Cell Differentiation 52
    出版社: Springer-Verlag Berlin Heidelberg
    DOI: 10.1007/978-3-642-14426-4

    简介

    The prevalence of obesity has dramatically increased in western and westernized societies, making the disease the second leading cause of unnecessary deaths in the US. Obesity results from imbalanced metabolic regulation leading to excessive lipid storage. As important novel entities in metabolic regulation, taste receptors and their cells are critical elements that adapt the gustatory system to metabolic signals and vice versa. The role of taste receptor genes in gastrointestinal tissues, as well as their dynamic regulation in gustatory and non-gustatory tissues in response to metabolic cues, has become the focus of an entirely new and rapidly developing research field with impacts on fuel sensing, metabolic control, and ingestive behavior. This book reflects the recent scientific progress in the field of fuel sensing in the mouth, GI tract, and brain and examines the olfactory bulb as a potential metabolic sensor and the brain-gut endocrine axis. It also touches on relevant novel molecular and cellular mechanisms regulating lipid storage and metabolism and covers the identification and functional characterization of obesity genes. Lastly, it illustrates the use of insect models to study relevant problems of energy homeostasis.



    目录
    Front Matter....Pages i-viii
    The Genetic Basis of Obesity and Type 2 Diabetes: Lessons from the New Zealand Obese Mouse, a Polygenic Model of the Metabolic Syndrome....Pages 1-11
    Regulation of Nutrient Metabolism and Inflammation....Pages 13-25
    Lipid Storage in Large and Small Rat Adipocytes by Vesicle-Associated Glycosylphosphatidylinositol-Anchored Proteins....Pages 27-34
    Autophagy and Regulation of Lipid Metabolism....Pages 35-46
    Gene Co-Expression Modules and Type 2 Diabetes....Pages 47-56
    Role of Zinc Finger Transcription Factor Zfp69 in Body Fat Storage and Diabetes Susceptibility of Mice....Pages 57-68
    Metabolic Sensing in Brain Dopamine Systems....Pages 69-86
    Oral and Extraoral Bitter Taste Receptors....Pages 87-99
    Reciprocal Modulation of Sweet Taste by Leptin and Endocannabinoids....Pages 101-114
    Roles of Hormones in Taste Signaling....Pages 115-137
    Endocannabinoid Modulation in the Olfactory Epithelium....Pages 139-145
    The Olfactory Bulb: A Metabolic Sensor of Brain Insulin and Glucose Concentrations via a Voltage-Gated Potassium Channel....Pages 147-157
    Energy Homeostasis Regulation in Drosophila : A Lipocentric Perspective....Pages 159-173
    Towards Understanding Regulation of Energy Homeostasis by Ceramide Synthases....Pages 175-181
    Role of the Gut Peptide Glucose-Induced Insulinomimetic Peptide in Energy Balance....Pages 183-188
    Adipocyte–Brain: Crosstalk....Pages 189-201
    Back Matter....Pages 203-205

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