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Drug Disposition and Pharmacokinetics: From Principles to Applications-[1]-[2011]-[pdf]-[Stephen H. Curry, Robin Whelpton]

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    发表于 2017-11-7 11:46:20 | 显示全部楼层 |阅读模式
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    书籍信息:
    标题: Drug Disposition and Pharmacokinetics: From Principles to Applications
    语言: English
    格式: pdf
    大小: 15.8M
    页数: 370
    年份: 2011
    作者: Stephen H. Curry, Robin Whelpton
    版次: 1
    出版社: Wiley

    简介

    This is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. The text provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus. A companion web site contains additional illustrations, further equations and numerous worked examples.Whilst this book has its roots in the highly acclaimed book of the same name, written by Stephen Curry nearly thirty years ago, it is essentially a new book having been restructured and largely rewritten. This readable and informative book is an invaluable resource for professionals and students needing to develop a rational approach to the investigation and application of drugs.


    目录
    Drug Disposition and Pharmacokinetics: From Principles to Applications......Page 1
    Editors......Page 2
    Copyright......Page 3
    Contents......Page 4
    Preface......Page 15
    About the Authors......Page 18
    1.Chemical Introduction: Sources,Classification and Chemical Properties of Drugs......Page 19
    2.Drug Administration and Distribution......Page 41
    3.Drug Elimination......Page 70
    4.Elementary Pharmacokinetics......Page 94
    5.More Complex and Model Independent Pharmacokinetic Models......Page 116
    6.Kinetics of Metabolism and Excretion......Page 137
    7.Further Consideration of Clearance,and Physiological Modelling......Page 153
    8.Drug Formulation: Bioavailability,Bioequivalence and Controlled-Release Preparations......Page 172
    9.Factors Affecting Plasma Concentrations......Page 184
    10.Pharmacogenetics and Pharmacogenomics......Page 201
    11.Developmental Pharmacology and Age-related Phenomena......Page 214
    12.Effects of Disease on Drug Disposition......Page 227
    13.Quantitative Pharmacological Relationships......Page 248
    14.Pharmacokinetic/Pharmacodynamic Modelling: Simultaneous Measurement of Concentrations and Effect......Page 259
    15.Extrapolation from Animals to Human Beings and Translational Science......Page 278
    16.Peptides and Other Biological Molecules......Page 288
    17.Drug Interactions......Page 301
    18.Drug Metabolism and Pharmacokinetics in Toxicology......Page 320
    19.Drug Monitoring in Therapeutics......Page 335
    Appendix.Mathematical Concepts and the Trapezoidal Method......Page 351
    Acknowledgements......Page 357
    Index......Page 358

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